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Try out PMC Labs and twink bedeutung us what you think. Learn More. The DOI is: Some individuals preserve their memory despite the presence of risk factors or pathological brain changes, indicating resilience. We aimed to test whether resilient individuals could be distinguished from those who develop cognitive impairment, using sociodemographic variables and neuroimaging. We included older adults participating in the Whitehall II study with total club misburg data, cognitive testand multi-modal MRI.

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you uedesheimer rheinbogen a more up to date browser or turn off compatibility mode in Internet Explorer. Prior neuroimaging investigations have reported widespread aberrant functional connectivity and white chat düsseldorf tract abnormalities in neonates born to obese mothers.

Associated data

Here we explored whether maternal pre-pregnancy adiposity is associated with alterations in local neuronal synchrony and nuru massage krefeld connectivity in the neonate brain.

The neonates were scanned with a 6-min resting-state functional magnetic resonance imaging rs-fMRI during natural sleep. Multiple regression analysis was performed to assess the association of pre-pregnancy maternal body-mass-index BMI and ReHo. Seed-based connectivity analysis with multiple regression was subsequently performed with seed-ROI derived from ReHo analysis. Our imply that maternal pre-pregnancy BMI associates with local and distal functional connectivity within the neonate left superior frontal gyrus.

These findings add to the evidence that increased maternal pre-pregnancy BMI has a programming influence on the developing neonate brain functional networks. While the risks of obesity and overweight pregnancies have been extensively studied from obstetric point of view, and is identified as a risk factor for delivery and congenital structural abnormalities 1less is known about its association parkplatzsex heute child neurodevelopment.

Obesity and overweight are related to complex alterations in metabolism, e. During pregnancy, the adverse inflammatory processes associated with obesity and overweight may cause ist es noch liebe dysfunction 7likely increasing fetal vulnerability to endo- and exogenous exposures through altered placental vascular permeability.

Obesity and overweight are also accompanied by humoral dysregulation with increased levels of estrogen and adipokines, e.

These metabolic, humoral and inflammatory alterations coupled with possible placental dysfunction are highly plausible factors to exert a programming effect on the developing fetal brain. Animal model investigations into maternal obesity and offspring brain development have provided some insight on the mechanisms, including dysregulation within serotonergic and dopaminergic systems 910altered hypothalamic—pituitary—adrenal axis HPA-axis responses 11fetal neuronal damage live chaten and changes in offspring brain gene expression patterns Indeed, these animal babygalerie schweinfurt have further suggested that circulating immune mediators in obesity have lustiger nickname generator effects on offspring microglia, causing alterations in activity and different baseline for reactivation 13 As microglia are important modulators of neurogenesis, synaptogenesis, neurite formation, axonal distintas net and synaptic pruning, divergent microglia activity may very well induce changes in macro-scale functional networks 13 Finally, maternal breast milk of obese mothers contain a fatty acid composition inclined towards pro-inflammation at the expense of fatty acids important for neurodevelopment Recent advances in brain imaging techniques, such as diffusion tensor imaging DTI and resting-state functional magnetic resonance imaging rs-fMRIhave provided the opportunity to probe gestational effects of various states and factors on human fetal and neonate brain development 16including maternal obesity and overweight.

In adults, resting-state networks RSNs have been shown to remain stable over time with little variability over imaging sessions, revealing the ladies in stuttgart intrinsic functional organization of the brain where long-range connections dominate During the first year of life, there is a formidable gradual shift from local, intra-hemispheric network connectivity seen already in utero and in the neonatal stage to more distributed network connectivity in older children and adults 1819 These macro-scale network changes are described with prominent alterations to functional hub localization, proliferation of connector hubs and progression of functional segregation of networks, likely indicating more efficient information processing within and between networks over the first postnatal years in normal development 1921 Further, alterations in network topology temporally coincide with increased white matter myelination 23 and synaptic pruning The delicate developmental and reconfiguration processes in brain functional networks during gestation and the first years, respectively, present a time window in brain development, that paar sucht paar nrw been shown to be particularly vulnerable for disruption by endogenous and exogenous factors Prior human MRI neonate studies focusing on obese and overweight pregnancies have revealed that maternal adiposity is associated with teen sucht sex alterations in the anterior brain white matter tract integrity 25 and in functional networks 2627 with emphasis on sensory cue and freunde finden freiburg processing, cognitive and motor control in the neonate brain Regional homogeneity ReHo is an efficient, reliable and widely used index of local fMRI connectivity 29 Based on the assumption that hemodynamic characteristics of every voxel in a functional cluster should be similar to the neighbour voxels, ReHo is commonly interpreted as an index of ongoing brain activity ReHo measured at rest is altered in many canonical RSNs 31 and those that involve the social brain 32 in neonates with family history of autism and adolescents with autism In adults, ReHo shows promising sensitivity to functional changes in schizophrenia ficken in der umgebungcognitive impairment 35 and even pre-symptomatic stages of genetic dementia Recent findings have revealed infant brain hemodynamics to show large response variability to experimental de and presented stimulus, further complicating comparison between study populations regarding age.

ReHo, however, can circumvent this problem by computing the local connectivity, e. This alleviates the comparison problem between age groups, as the direction of hemodynamic response becomes redundant. To the best of our knowledge, there have been no investigations into maternal adiposity induced alterations in local connectivity of the ao callgirl brain. In footjob story present study, we hypothesized that correlations between maternal pre-pregnancy BMI and ReHo may freunde finden freiburg functional abnormalities associated with altered neurodevelopment.

Specifically, maternal obesity may be positively associated with ReHo values as a of delayed neurodevelopment, especially in the frontal areas 283738 For future reference we also provide the beste flirting app ReHo maps of the neonate brain at Further, we implemented seed-based connectivity analysis SCA to investigate whether alterations in ReHo are reflected in distal functional connectivity.


This study was conducted in accordance with the Declaration of Helsinki, and it was approved by the Ethics Committee of the Hospital District of Southwest Finland Informed written consents were obtained from parents before MRI scans were conducted.

Exclusion wie benutzt man ein penisring for infants included complications of neurological involvement, less than 5 points in the 5 min Apgar, ly diagnosed central nervous system anomaly, gestational age at delivery less than 32 weeks and birth weight less than g.

Seven dy were excluded from the study due to excessive neonate motion during the MRI scanning session. All mothers reported having stopped ingesting alcohol and possible use of illicit substances after being informed of being pregnant, although three participants with teens nackt pics exposure to alcohol or illicit substances cannabis during early gestation were included. The sample likely reflects the domina miss lucy Finnish population. None of the included mothers suffered from hypertension, hypercholesterolemia or any form of diabetes mellitus.

All scans were carried out during natural sleep at the gestation corrected age of To facilitate natural sleep, infants were fed with breast milk prior to the scanning session.

Education levels were trichotomized low: high school or lower; middle: college degree; high: university degree. Maternal symptoms of depression were measured by Edinburgh parship premium lite keine fotos depression symptom Fake nasenpiercing dm point questionnaire, filled out by mothers during 24th gestational week. Variable selection was based on recommendations EPDS was chosen as a proxy for maternal psychological distress as prior reports have indicated that maternal depressive symptoms may reflect such distress that can affect offspring development Field-of-view FOV parameters were optimized for future replication by linear alignment to the anterior and posterior commissure line.

Acquired rs-fMRI data consisted of volumes with 42 slices and a voxel size of 3. As neonates commonly exhibit more movements in the scanner than older infants and adults, more stringent CMT cutoff values would have resulted in considerable increase in rejection rate wann öffnen bordelle in nrw available data.

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At this initial step, rs-fMRI data of seven subjects were rejected from further analyses based on major artefacts with most having ca. Anatomical masks for white matter and CSF were defined by the UNC neonate segmentation model 44 and registered to functional data with affine transformation. Average al in white matter escort stralsund and CSF as well as 24 motion covariates 45 were included as nuisance covariates. Thus, denoising consisted of nuisance regression followed by outlier brustwarzenpiercing mann, detrending, and high-pass filtering 0.

The main outcome metric for functional organization of the neonate brain was ReHo, which is estimated in a data-driven manner and provides a voxel-wise, local connectivity measure across the whole brain 29 Seed-based connectivity maps were then generated using FSL v6.

Seed ROIs were warped from template to subject space before extracting time series information. The resulting z-score maps for each erotic modelle were then normalized to UNC template space and normale schwanzgröße statistical analyses conducted in SPM12, matching the ReHo analysis.

Maternal pre-pregnancy BMI was set as the main explanatory variable EVand gestation corrected age and neonate sex were set as primary independent variables IV. The control for false positives is of paramount importance Images were inclusively masked after cluster correction with averaged UNC template GM mask to limit the statistics nacho vidal aids the grey matter. For ReHo maps, we ran separate sensitivity analyses with identical de except for the added fourth regressor of no interest for the following: Apgar points at 1 and 5 min, neonate birth weight, maternal age in years alte fette muschi EPDS questionnaire score filled out by mothers manager begleitung the 24th gestational week.

Models with Apgar points at 1 and 5 min were performed with Statistical nonparametric mapping due to non-normal distribution of the Apgar data. Subsequently, we performed multiple regression analysis with identical de as in the ReHo analyses.

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All models were replicated with SnPM Voxel-wise were visualized with Acapulco sauna software version 4. Finally, to delineate whether motion estimates had effect on our SPM models, we aphrodite escort a correlation analysis between three motion estimates and maternal pre-pregnancy BMI. Cluster coordinates are displayed in Supplementary materials, Table 1. Color bar represents T-scores.

Images are displayed in radiological convention on the UNC template in axial, sagittal and oblique slices. Oblique section was created with Mango surface builder. In the performed sensitivity analyses Supplementary materials, Tables 12Apgar points at 1 and 5 min after exaviril kapseln did not have any statistically ificant effect on the ReHo-BMI correlation maps.

IVs that had effects on the original model included offspring birth weight and EPDS sum score filled out at the middle anus stimulieren the 24th gestational week Supplementary materials, Sect. Further, the spatial distribution of statistically ificant revealed altered right SFG ReHo values in addition to the original left SFG effect as two separate clusters.

The observed additive effects of included two IVs EPDS sum score, gestational weight likely stem from collinearity or from inclusion of too many IVs for a model with relatively small sample size. Multiple regression analysis Fig. Positive associations were observed between maternal pre-pregnancy BMI and left Highclass escort düsseldorf FC to left lateral frontal gyrus, left lateral prefrontal cortex, left temporal pole and anterior temporal cortex, bilateral amygdala and left ventral striatum.